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Latest Research : Pharmacology : Anticholesterol
  Last Updated: Nov 2, 2013 - 11:52:55 AM

Latest Research
NIH clinical trial begins for treatment of rare, fatal neurological disorder
A clinical trial to evaluate a drug candidate called cyclodextrin as a possible treatment for Niemann-Pick disease type C1 (NPC), a rare and fatal genetic disease, will start today, researchers announced. Scientists from the NIH's National Center for Advancing Translational Sciences (NCATS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) will conduct the clinical trial at the NIH Clinical Center. Reaching this trial stage required collaboration among government, industry, patient advocacy groups and academic researchers.
Jan 23, 2013 - 5:00:00 AM

Latest Research
Moderate coffee consumption may reduce risk of diabetes by up to 25 percent
Drinking three to four cups of coffee per day may help to prevent type 2 diabetes according to research highlighted in a session report published by the Institute for Scientific Information on Coffee (ISIC), a not-for-profit organisation devoted to the study and disclosure of science related to coffee and health.
Dec 4, 2012 - 5:00:00 AM

Latest Research
Low vitamin D level is linked to greater chance of risk factors for Type 2 diabetes
A new study presents more evidence of a possible link between low vitamin D levels and a higher risk of Type 2 diabetes and heart disease. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.
Jun 25, 2012 - 4:00:00 AM

Latest Research
Liraglutide with insulin improves poorly controlled Type 1 diabetes
Obese adults with poorly controlled Type 1 diabetes can better control their blood sugar by adding liraglutide, a Type 2 diabetes drug, to their insulin therapy, a new study finds. The results, which will be presented Sunday at The Endocrine Society's 94th Annual Meeting in Houston, also found that these diabetic patients lost weight and lowered their blood pressure.
Jun 24, 2012 - 4:00:00 AM

Latest Research
Risk score could lead to better diagnosis of the metabolic syndrome in children
Researchers have developed a new scoring system that may better identify adolescents with the metabolic syndrome, a group at increased risk of later developing Type 2 diabetes and heart disease. The study, to be presented Sunday at The Endocrine Society's 94th Annual Meeting in Houston, describes what the authors call the first racial/ethnic-specific and sex-specific scoring system for the metabolic syndrome.
Jun 24, 2012 - 4:00:00 AM

Latest Research
Exercise with diet improves insulin sensitivity much more than diet alone
Obese older adults can reduce their chance of developing the metabolic syndrome by losing weight through dieting alone, but adding exercise to a weight loss program has even more benefit, a new study finds. The results, to be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston, show that a combination of diet-induced weight loss and frequent exercise almost doubled the improvement in insulin sensitivity compared with dieting alone.
Jun 23, 2012 - 4:00:00 AM

Latest Research
Moderate drinking associated with lower risk of stroke in women
Light-to-moderate alcohol consumption has been consistently associated with lower risk of heart disease, but data for stroke are less certain, especially among women.
Mar 15, 2012 - 4:00:00 AM

Latest Research
Psoriasis is associated with impaired HDL function, Penn study finds
Orlando - Collaborative research from Perelman School of Medicine at the University of Pennsylvania has shown that psoriasis patients have an increased risk of heart attack, stroke and cardiovascular death, especially if the psoriasis is moderate to severe. Now, Penn researchers have discovered the potential underlying mechanism by which the inflammatory skin disease impacts cardiovascular health. In two new studies presented at the 2011 American Heart Association Scientific Sessions, Penn researchers show that the systemic inflammatory impact of psoriasis may alter both the makeup of cholesterol particles and numbers, as well as impair the function of high density lipoprotein (HDL), the good cholesterol.
Nov 16, 2011 - 5:00:00 AM

Latest Research
NIH stops clinical trial on combination cholesterol treatment
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped a clinical trial studying a blood lipid treatment 18 months earlier than planned. The trial found that adding high dose, extended-release niacin to statin treatment in people with heart and vascular disease, did not reduce the risk of cardiovascular events, including heart attacks and stroke.
May 26, 2011 - 4:00:00 AM

Latest Research
Cholesterol-lowering drug shrinks enlarged prostates in hamster model
Boston, Mass. - A cholesterol-lowering drug reduced the enlarged prostates of hamsters to the same extent as a drug commonly used to treat benign prostatic hyperplasia (BPH), report researchers at Children's Hospital Boston and their colleagues in the October issue of the Journal of Urology. Together, the drugs worked even better.
Oct 21, 2010 - 4:00:00 AM

Latest Research
Even the boss doesn't follow the doctor's orders
ANN ARBOR, Mich.---Only 68 percent of corporate executives took their cholesterol lowering medication as prescribed by a doctor, a new study shows.
Mar 2, 2010 - 5:00:00 AM

Latest Research
Changes during menopause increases risk of heart disease and stroke
CHICAGO- When women hear the word menopause, they often think about hot flashes, hormone shifts and mood swings. But what about heart disease? Studies show a woman's risk of heart disease intensifies drastically around the time of natural menopause, which for most women is around the age of 50. This news may come as a surprise, but experts explain that understanding risk factors is an important first step, and reassure women that there are ways to lower your risk.
Feb 23, 2010 - 5:00:00 AM

Latest Research
Statins may worsen symptoms in some cardiac patients
Although statins are widely used to prevent heart attacks, strokes, and other cardiovascular disorders, new research shows that the class of drugs may actually have negative effects on some cardiac patients. A new study presented at CHEST 2009, the 75th annual international scientific assembly of the American College of Chest Physicians (ACCP), found that statins have beneficial effects on patients with systolic heart failure (SHF), but those with diastolic heart failure (DHF) experienced the opposite effect, including increased dyspnea, fatigue, and decreased exercise tolerance.
Nov 3, 2009 - 5:00:00 AM

Latest Research
Low cholesterol may shrink risk for high-grade prostate cancer
Men with lower cholesterol are less likely than those with higher levels to develop high-grade prostate cancer - an aggressive form of the disease with a poorer prognosis, according to results of a Johns Hopkins collaborative study.
Nov 3, 2009 - 5:00:00 AM

Latest Research
Lap-band weight-loss surgery can reverse metabolic syndrome in obese teens
NEW YORK (June 30, 2009) -- A new study of obese adolescents has shown that laparoscopic gastric banding surgery -- the Lap-Band procedure -- not only helps them achieve significant weight loss but can also improve and even reverse metabolic syndrome, reducing their risk for cardiovascular disease and diabetes.
Jul 1, 2009 - 4:00:00 AM

Latest Research
Study: Vibration plate machines may aid weight loss and trim abdominal fat
Amsterdam, the Netherlands: New research suggests that, if used properly, vibration plate exercise machines may help you lose weight and trim the particularly harmful belly fat between the organs.
May 8, 2009 - 4:00:00 AM

Latest Research
Increased food intake alone explains the increase in body weight in the United States
Amsterdam, the Netherlands: New research that uses an innovative approach to study, for the first time, the relative contributions of food and exercise habits to the development of the obesity epidemic has concluded that the rise in obesity in the United States since the 1970s was virtually all due to increased energy intake.
May 8, 2009 - 4:00:00 AM

Latest Research
Genes for 9 health indicators
A new genome-wide study examines genetic variants associated with nine metabolic traits and is the first to draw out novel variants from a population unselected for current disease. The traits are indicators for common disease such as cardiovascular disease, type 2 diabetes, blood pressure, inflammation and lipid levels.
Dec 7, 2008 - 5:00:00 AM

Latest Research
Statins can provide some protection against dementia
Cholesterol-lowering drugs known as statins have a profound effect on an elite group of cells important to brain health as we age, scientists at the University of Rochester Medical Center have found. The new findings shed light on a long-debated potential role for statins in the area of dementia.

Jul 3, 2008 - 4:00:00 AM

Latest Research
Study: highly involved patients don't always see better health outcomes
Patients who prefer to be highly involved in their treatment don't necessarily have better luck managing chronic health conditions, a new study suggests.
Feb 22, 2008 - 5:00:00 AM

Latest Research
Intensive blood sugar treatment in trial of diabetes and cardiovascular disease changed
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped one treatment within a large, ongoing North American clinical trial of diabetes and cardiovascular disease 18 months early due to safety concerns after review of available data, although the study will continue.

Feb 6, 2008 - 11:40:00 PM

Latest Research
Role of a key enzyme in reducing heart disease identified
Virginia Commonwealth University researchers have identified the role of a key enzyme called CEH in reducing heart disease, paving the way for new target therapies to reduce plaques in the arteries and perhaps in the future, help predict a patient’s susceptibility to heart disease.
Oct 24, 2007 - 4:00:00 AM

Latest Research
Cholesterol metabolism links early- and late-onset Alzheimer's disease
Oct. 4, 2007 -- Although the causes of Alzheimer's disease are not completely understood, amyloid-beta (A-beta) is widely considered a likely culprit — the sticky protein clumps into plaques thought to harm brain cells.
Oct 4, 2007 - 4:00:00 AM

Latest Research
Low maternal cholesterol tied to premature birth
Pregnant women who have very low cholesterol may face a greater risk of delivering their babies prematurely than women with more moderate cholesterol levels, a team led by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), reported today.
Oct 1, 2007 - 4:00:00 AM

Latest Research
'Bad carbs' not the enemy, University of Virginia professor finds
The latest common wisdom on carbohydrates claims that eating so-called “bad” carbohydrates will make you fat, but University of Virginia professor Glenn Gaesser says, “that’s just nonsense.” Eating sandwiches with white bread, or an occasional doughnut, isn't going to kill you, or necessarily even lead to obesity, he said.
Sep 28, 2007 - 4:00:00 AM

Latest Research
Treating obstructive sleep apnea, preventing heart attacks and strokes
Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries. Until now, no study has demonstrated such a direct relationship between the two.
Sep 28, 2007 - 4:00:00 AM

Latest Research
Metabolic study in mice could lead to 'good cholesterol' boosters
Researchers have identified a new player in the control of so-called “good” cholesterol that circulates in the bloodstream and reduces heart attack risk, according to a report in the August issue of Cell Metabolism, a publication of Cell Press. Should the metabolic pathway uncovered in mice operate similarly in humans, the new discovery could point the way to therapies that protect against heart disease by boosting concentrations of the beneficial high-density lipoprotein cholesterol (HDL-C).
Aug 7, 2007 - 4:00:00 AM

Latest Research
Older is better -- Top-10 comparison of diabetes drugs give metformin top grade
A type 2 diabetes drug taken orally and in widespread use for more than a decade has been found to have distinct advantages over nine other, mostly newer medications used to control the chronic disease, according to a study by researchers at Johns Hopkins.
Jul 24, 2007 - 4:00:00 AM

Latest Research
Bak protein sets stressed cells on suicide path, researchers show
When a cell is seriously stressed, say by a heart attack, stroke or cancer, a protein called Bak just may set it up for suicide, researchers have found.
Jul 12, 2007 - 4:00:00 AM

Latest Research
Insulin sensitizer also serves as energy-conserving signal to the brain
A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation, suggests a new study in the July issue of Cell Metabolism, a publication of Cell Press. The substance, known as adiponectin, acts on the brain to boost appetite and slow energy expenditure in an effort to maintain adequate fat stores during lean times, the researchers report.
Jul 10, 2007 - 4:00:00 AM

Latest Research
New heart disease risk score will help minimize health inequalities
A new score for predicting the risk of heart disease gives a more accurate measure of how many UK adults are at risk of developing the disease — and which adults are most likely to benefit from treatment.
Jul 6, 2007 - 4:00:00 AM

Latest Research
Protein's role in lipid absorption may be important to future weight-loss strategies
July 5, 2007 -- Researchers at Washington University School of Medicine in St. Louis have found that a protein absorbs lipids in the upper part of the intestine, and they believe its key role in this process may provide a novel approach for obesity treatment in the future.
Jul 5, 2007 - 4:00:00 AM

Latest Research
Weight management program cuts diabetes risk, improves BMI in overweight children
A family-based weight management program developed by researchers at Yale School of Medicine was more effective at reducing weight, body fat, body mass index (BMI) and insulin sensitivity than traditional clinic-based weight counseling.
Jun 26, 2007 - 4:00:00 AM

Latest Research
Diachrome improves blood sugar control in people with type 2 diabetes
Nutrition 21, Inc. today announced new published results from a 447 subject, randomized, double-blind, placebo-controlled clinical study that showed Diachrome, a patented combination of chromium picolinate and biotin, significantly improved glycemic control in patients with poorly controlled blood sugar levels who were being treated with oral anti-diabetic medication (OADs). Patients in the treatment group showed significant improvements in glycemic control (A1C) compared with placebo (an absolute decrease of 0.54%). The greatest improvement was seen in those patients with the poorest glycemic control (baseline A1C levels equal to or greater than 10%). These patients saw an additional absolute A1C decrease of 1.76% despite the fact that they were taking one or more OAD medications.
Jun 5, 2007 - 4:00:00 AM

Latest Research
Exercise may slightly boost 'good' cholesterol levels
Regular exercise appears to modestly increase levels of high-density lipoprotein, or good, cholesterol, according to a meta-analysis study in the May 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
May 28, 2007 - 4:00:00 AM

Latest Research
Reducing cardiovascular disease risk factors when discontinuing hormone replacement therapy
Hormone replacement therapy (HRT) has been shown to reduce many cardiovascular disease (CVD) risk factors, but many women have stopped using HRT due to reports from the WomenÂ’s Health Initiative that HRT may increase the risk of breast cancer and heart disease. In a study published in the June issue of the American Journal of Preventive Medicine, researchers from the University of Pittsburgh Graduate School of Public Health examined whether the increased CVD risk from stopping HRT could be minimized by lifestyle change intervention.
May 15, 2007 - 4:00:00 AM

Latest Research
Employee health program improves blood pressure, diabetes control
WASHINGTON, May 10 – Employees who participated in a worksite health program improved blood pressure control by 9 percent and diabetes control by 15 percent, researchers reported at the American Heart Association's 8th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke.
May 10, 2007 - 4:00:00 AM

Latest Research
MU researchers find statin drugs also may help reduce risk of heart failure, sudden cardiac death
COLUMBIA, Mo. -- Statin drugs, known primarily for their ability to lower cholesterol, also may reduce the overactive sympathetic nervous system response that contributes to the worsening of heart failure and increases the risk of sudden cardiac death, two University of Missouri-Columbia researchers have found. Heart failure is the leading cause of morbidity and mortality in the United States.
May 1, 2007 - 4:00:00 AM

Latest Research
Higher trans fat levels in blood associated with elevated risk of heart disease
Boston, MA -- High consumption of trans fat, found mainly in partially hydrogenated vegetable oils and widely used by the food industry, has been linked to an increased risk of coronary heart disease (CHD). New York and Philadelphia have passed measures eliminating its use in restaurants, and other cities are considering similar bans. A new study from the Harvard School of Public Health (HSPH) provides the strongest association to date between trans fat and heart disease. It found that women in the U.S. with the highest levels of trans fat in their blood had three times the risk of CHD as those with the lowest levels. The study was published online on March 26, 2007, and will appear in the April 10, 2007 print issue of Circulation: Journal of the American Heart Association.
Mar 27, 2007 - 4:00:00 AM

Latest Research
Infusion with reconstituted HDL may have some benefit for atherosclerosis
Preliminary research suggests that use of reconstituted HDL may have some benefit in coronary atherosclerosis, according to a JAMA study published online March 26. The study is being released early to coincide with its presentation at the American College of Cardiology's annual conference.
Mar 26, 2007 - 4:00:00 AM

Latest Research
Single genetic defect causes early heart disease
A team of researchers from the United States and Iran has identified a genetic mutation that causes early onset coronary artery disease in members of a large Iranian family. The genetic mutation leads to heart disease by causing high blood pressure, high blood levels of bad cholesterol and diabetes, all risk factors for heart disease. Coronary artery disease is the leading cause of death worldwide.
Mar 1, 2007 - 5:00:00 AM

Latest Research
Pharmacist-driven outreach lowers metabolic syndrome rates
ORLANDO, Fla., Feb. 28 -- Adults who met with pharmacists or pharmacy students during a community outreach and screening project about metabolic syndrome, returned four months later with lower risk factors for heart disease, researchers reported today at the American Heart AssociationÂ’s 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.
Feb 28, 2007 - 5:00:00 AM

Latest Research
Garlic does not appear to lower cholesterol levels
Three forms of garlic—including raw garlic and two types of commercial garlic supplements—did not significantly reduce low-density lipoprotein (LDL or bad) cholesterol during a six-month trial, according to results published in the February 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Feb 26, 2007 - 5:00:00 AM

Latest Research
Statin users risk heart attacks by dropping treatment or taking low doses
Thousands of statin users worldwide are suffering preventable heart attacks, simply because they are not complying with their treatment or are taking too low a dose, according to new research published on-line (Thursday 7 December) in European Heart Journal[1].
Dec 6, 2006 - 5:00:00 AM

Latest Research : Pharmacology : Anticholesterol : Torceptrapib
ILLUMINATE study: Pfizer Stops All Torcetrapib Clinical Trials
FDA was notified that Pfizer will suspend a large, Phase 3 trial evaluating the investigational cardiovascular therapy torceptrapib/atorvastatin (T/A) due to an increased rate of mortality (death) in patients receiving the combination compared to those receiving atorvastatin alone. With the T/A development program, as it does with all such development programs, FDA assured that Pfizer had the appropriate protections in place for patients participating in the drug’s development, including informed consent, a Data Safety Monitoring Board (DSMB) for its outcome study, and that the development program was done in a careful, stepwise manner.
Dec 3, 2006 - 5:48:26 PM

Latest Research
Weight cycling associated with increased risk for gallstones among men
Intentionally losing weight and then regaining it may increase menÂ’s risk for gallstones later in life, according to a report in the November 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Nov 27, 2006 - 5:00:00 AM

Latest Research
A little TLC goes a long way toward reducing high cholesterol
If you're one of the nearly 65 million Americans with high blood cholesterol, National Cholesterol Education Month (September) is a perfect time to read a new publication designed to help you make the lifestyle changes needed to reduce cholesterol and, with it, your risk for heart disease.
Aug 24, 2006 - 4:00:00 AM

Latest Research
Aggressive reduction in cholesterol levels can reduce risk for stroke by 16 percent
NORTH CHICAGO, ILL. (August 10, 2006) – According to data from the National Stroke Association, up to 40 percent of patients who have had a stroke will experience a second stroke within five years of the first. An international team of researchers recently completed a study to determine if the cholesterol-lowering drug Lipitor® (atorvastatin calcium) would reduce the occurrence of a second stroke. The Stroke Prevention by Aggressive Reduction of Cholesterol Levels (SPARCL) team of investigators, led by Dr. K. Michael Welch, neurologist and President and CEO of Rosalind Franklin University of Medicine and Science, published their research in today's issue of the New England Journal of Medicine.
Aug 9, 2006 - 4:00:00 AM

Latest Research
Study indicates widely-used nutritional supplement does not improve cholesterol levels
Policosanol is a natural substance produced from the waxy coating of sugar cane. Cuban sugar cane policosanol is sold in more than 40 countries mainly because of its supposed lipid-lowering effects, according to background information in the article. Numerous policosanol products from a variety of sources (sugar cane, wheat germ, rice bran, beeswax) are available over-the-counter and on the Internet in several countries. Advertising emphasizes predominantly its reputed lipid-lowering effects, comparable with statins (prescription medications taken to lower cholesterol). Most of the published scientific literature, more than 80 trials, supporting the beneficial effects of policosanol on lipids has been authored by a single research group from Cuba. One clinical trial from the Netherlands showed wheat germ–derived policosanol ineffective in lowering total cholesterol and low-density lipoprotein cholesterol (LDL-C), sometimes called bad cholesterol.
May 16, 2006 - 4:00:00 AM

Latest Research
Markers of PCOS inherited, persist and raise risk for heart disease, diabetes
That finding is reported in a new study published April 17 in the early online edition of the Proceedings of the National Academy of Sciences (
Apr 17, 2006 - 4:00:00 AM

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