Newer Nonionic Contrast Agents Safe for Children
Jun 7, 2007 - 9:35:07 PM
, Reviewed by: Dr. Rashmi Yadav
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"We performed our study because we wanted to find out what the exact risk of allergic reactions to these newer contrast agents was in children"
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Level of Evidence
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2b - Individual Cohort Study
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By AARS,
[RxPG] Allergic-like reactions to newer iodine-containing contrast agents (nonionic contrast media), are rare in children according to a recent study conducted by researchers from the University of Michigan Medical Center and C.S. Mott Childrenâs Hospital both in Ann Arbor.
âA major, if not the main, risk associated with iodine-containing contrast agents is allergic types of reactions. Such reactions can be mild; for example, hives or severe such as difficulty breathing or even cardiopulmonary arrest,â said Jonathan R. Dillman, MD, lead author of the study.
âOver the past 20 years, we have changed the type of iodine-containing intravenous contrast agents used primarily for computed tomography (CT) and intravenous pyelogram (IVP) examinations in both adult and pediatric patients. The nonionic contrast media that we now use have been studied extensively in adults, but not as much in children. We performed our study because we wanted to find out what the exact risk of allergic reactions to these newer contrast agents was in children,â said Dr. Dillman.
The study evaluated 11,306 pediatric IV administrations of iodine-containing contrast agents over a seven year period. According to the study, acute allergic-like reactions were documented in 20 of the patients. Of these patients, 16 of the allergic-like reactions were categorized as mild, one as moderate, and three as severe. Six of the reacting patients had a history of allergic-like reactions, including two patients who had a history of reactions to iodinated contrast material. Five of the patients had a history of asthma.
âWhile we have long assumed that newer nonionic contrast agents are safe, this study re-affirms their safety and better determines what the risks actually are in children,â said Richard H. Cohan, MD, co-author of the study. âOur study confirms that doctors and parents alike can feel comfortable administering these agents to children,â he said.
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About Dr. Rashmi Yadav
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This news story has been reviewed by Dr. Rashmi Yadav before its publication on RxPG News website. Dr. Rashmi Yadav, MBBS, is a senior editor for RxPG News. In her position she is responsible for managing special correspondents and the surgery section of the website. Her areas of special interest include cardiothoracic surgery and interventional radiology.
RxPG News is committed to promotion and implementation of Evidence Based Medical Journalism in all channels of mass media including internet.
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Additional information about the news article
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The American Roentgen Ray Society (ARRS) was founded in 1900 and is the oldest radiology society in the United States. Its monthly journal, the American Journal of Roentgenology, began publication in 1906 and has Japanese and Chinese editions. Radiologists from all over the world attend the ARRS Annual Meeting to take part in instructional courses, scientific paper presentations, symposia, new issues forums and scientific and commercial exhibits related to the field of radiology. The Society is named after the first Nobel Laureate in Physics, Wilhelm Röentgen, who discovered the X-ray in 1895.
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