The authors also show that high oxygen concentration stimulates A1, that A1 regulates death of cells in the lung, and that it plays a central role in the induction of other proteins that modulate programmed cell death. In mice lacking A1, the harmful effects of oxygen are intensified whereas overexpressing A1 decreases lung cell death in the presence of oxygen.
By Journal of Clinical Investigation, [RxPG] Patients with lung and heart disease are commonly given supplemental oxygen, however very high concentrations of oxygen administered for extended periods of time can trigger lung injury.
The mechanism underlying this lung injury has not been characterized. In a study appearing in the April 1 issue of The Journal of Clinical Investigation, Jack Elias and colleagues from Yale University demonstrate that a protein called A1 is a critical regulator in this type of lung injury.
The authors also show that high oxygen concentration stimulates A1, that A1 regulates death of cells in the lung, and that it plays a central role in the induction of other proteins that modulate programmed cell death. In mice lacking A1, the harmful effects of oxygen are intensified whereas overexpressing A1 decreases lung cell death in the presence of oxygen.
In an accompanying commentary, G.R.Scott Budinger and Jacob Sznajder writes that these studies will "influence future investigations into the molecular mechanisms by which these [A1] pathways become activated to contribute to lung injury."
Publication:
TITLE: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxia acute lung injury
On the web:View the PDF of this article commentary
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TITLE: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxia acute lung injury
AUTHOR CONTACT:
Jack Elias
Yale University School of Medicine, New Haven, Connecticut, USA.
Phone: (203) 785-4163; Fax: (203) 785-3826; E-mail: [email protected]
View the PDF of this article at:
ACCOMPANYING COMMENTARY:
TITLE: To live or die: a critical decision for the lung
AUTHOR CONTACT:
Jacob I. Sznajder
Northwestern University, Chicago, Illinois, USA.
Phone: (312) 908-8163; Fax: (312) 908-4650; E-mail: [email protected]
View the PDF of this article at: https://www.the-jci.org/article.php?id=24681
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