RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
   Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
  Anorexia Nervosa
  Anxiety
  Bulimia
  CFS
  Child Psychiatry
  Depression
  Forensic Psychiatry
  Learning-Disabilities
  Mood Disorders
  Neuropsychiatry
  Peri-Natal Psychiatry
  Personality Disorders
  Psychology
  Psychoses
   Bipolar Disorder
   Schizophrenia
  Psychotherapy
  Sleep Disorders
  Substance Abuse
  Suicide
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Journal of Clinical Investigation Schizophrenia Channel

subscribe to Schizophrenia newsletter
Latest Research : Psychiatry : Psychoses : Schizophrenia

   EMAIL   |   PRINT
Possible genetic link to schizophrenia identified

Feb 9, 2007 - 2:53:10 AM , Reviewed by: Dr. Ankush Vidyarthi
Preliminary analysis indicated that this variant was associated with an increased risk of schizophrenia, although further studies will be necessary to confirm this association.

 
[RxPG]
Possible genetic link to schizophrenia identified
One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. However, very little is known about the function of this protein in humans.
Several neurological and psychiatric disorders, including schizophrenia, alcoholism, and Parkinson’s disease, are associated with changes in the brain that affect the nerves that communicate with each other through the naturally-produced chemical dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. However, very little is known about the function of this protein in humans.

In a study appearing online on February 8 in advance of publication in the March print issue of the Journal of Clinical Investigation, Daniel Weinberger and colleagues from the National Institutes of Health show that the gene that encodes DARPP-32 exhibits genetic variation. One particular variant that increased expression of the mRNA encoding DARPP-32 in the brain was associated with increased performance in a number of cognitive tests, including IQ and memory tests. This variant was also associated with changes in the structure and function of part of the brain known as the neostriatum, as well as changes in the ability of the neostriatum to communicate with the frontal lobe. Importantly, preliminary analysis indicated that this variant was associated with an increased risk of schizophrenia, although further studies will be necessary to confirm this association.


Original research article: https://www.the-jci.org/article.php?id=30413 
Publication: Journal of Clinical Investigation
On the web: http://www.jci.org/ 

Advertise in this space for $10 per month. Contact us today.


Related Schizophrenia News
Nicotine may be a treatment for some symptoms of schizophrenia
People With Schizophrenia Face Increased Risk Of Diabetes - Research
Brain recruiting pattern incorrect in Schizophrenic patients
Schizophrenia Risk Gene DISC1 Plays a Broader Role in the Development of Nervous System
Chemical maps hint at drug's effects on schizophrenia
Study challenges idea that schizophrenia is distinct in developing and developed regions
New details in schizophrenia treatment trial emerge
Abnormalities in eye movements and attention can predict risk of Schizophrenia
Possible genetic link to schizophrenia identified
Brain scan may help doctors predict schizophrenia

Subscribe to Schizophrenia Newsletter

Enter your email address:


 About Dr. Ankush Vidyarthi
This news story has been reviewed by Dr. Ankush Vidyarthi before its publication on RxPG News website. Dr. Ankush Vidyarthi, MBBS is a senior editor of RxPG News. He is also managing the marketing and public relations for the website. In his capacity as the senior editor, he is responsible for content related to mental health and psychiatry. His areas of special interest are mass-media and psychopathology.
RxPG News is committed to promotion and implementation of Evidence Based Medical Journalism in all channels of mass media including internet.
 Additional information about the news article
TITLE: Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition

AUTHOR CONTACT:
Daniel R. Weinberger
National Institute for Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Phone: (301) 402-7564; Fax: (301) 480-7795; E-mail: [email protected]
 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)