||Last Updated: Nov 17th, 2006 - 22:35:04
Cyclin-dependent kinase inhibitors: The latest anti-inflammatory
People who suffer from inflammatory conditions such as chronic diseases of the lung, joints and other organs could benefit from a new discovery by scientists at the University of Edinburgh. A new study in Nature Medicine journal shows that certain drugs, already being tested as cancer treatments, can dramatically reduce tissue inflammation.
Sep 4, 2006, 16:41
Ibuprofen - worsening cognitive function
Researchers at the University of Pennsylvania School of Medicine found that chronic ibuprofen therapy given after brain injury worsens cognitive abilities. These findings – in a preliminary, animal-model study – have important implications for traumatic brain injury (TBI) patients who are often prescribed such nonsteroidal anti-inflammatory drugs (NSAIDS) as ibuprofen for chronic pain.
Jul 22, 2006, 05:22
COX 2 inhibitors associated with increased risk of vascular events
High doses of some traditional non-steroidal anti-inflammatory drugs (NSAIDS) are associated with similar cardiovascular risks as the new generation of anti-inflammatory drugs known as COX 2 inhibitors (like Vioxx ®), finds a study in this week's BMJ.
Jun 2, 2006, 22:55
Therapeutic prospects beyond COX -2 inhibitors
Researchers at the University of Pennsylvania School of Medicine have clarified the mechanism by which COX -2 inhibitor drugs like Celebrex and Vioxx cause heart problems, in multiple animal models. The findings offer the prospect of a new generation of anti-inflammatory drugs that bypass this issue, as reported in the April 13 online edition and May print issue of The Journal of Clinical Investigation.
Apr 15, 2006, 08:42
Ceramide Kinase (CERK) may be a target for new anti-inflammatory drugs
Virginia Commonwealth University researchers studying the enzyme that triggers inflammation have found that it may be a target for a new class of anti-inflammatory drugs to treat arthritis, asthma, multiple sclerosis, lung and colon cancers and Alzheimer’s disease.
Dec 4, 2005, 10:22
No evidence for greater stomach protection by Cox-2 Inhibitors
There is no evidence to back up claims that the new generation of anti-inflammatory drugs (COX-2 inhibitors) are less harmful to the stomach lining than many traditional anti-inflammatory drugs, concludes a study in this week’s BMJ.
Dec 2, 2005, 19:14
European Medicines Agency update on non-selective NSAIDs
The Agency’s scientific committee, the Committee for Medicinal Products for Human Use (CHMP), concluded, at its meeting of 10-13 October 2005, that, on the basis of the data reviewed, there are no new safety concerns regarding cardiovascular and gastrointestinal safety and serious skin reactions with non-selective NSAIDs (non-steroidal anti-inflammatory drugs). NSAIDs remain important treatments for arthritis and other painful conditions.
Oct 17, 2005, 19:05
NSAIDS and Cox 2 inhibitors increase risk of MI - Study
Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
Jun 12, 2005, 20:48
Eszopiclone Cost Effective in Long-Term Treatment of Insomnia
Sepracor Inc. (Nasdaq: SEPR - News) announces the presentation of results from two analyses designed to assess potential pharmacoeconomic benefits associated with the use of LUNESTA(TM) brand eszopiclone in the long-term treatment of insomnia.
May 17, 2005, 19:26
FDA asks Pfizer to withdraw Bextra and add boxed warning to Celebrex
The Food and Drug Administration ( FDA ) today announced a series of important changes pertaining to the marketing of the non-steroidal anti-inflammatory class of drugs, including COX-2 selective and prescription and non-prescription ( over-the-counter ( OTC ) ) non-selective NSAID medications.
Apr 8, 2005, 10:16
COX 2 Inhibitors for Colorectal Adenoma Prevention Increase Serious Cardiovascular Events
Researchers affiliated with the Adenoma Prevention with Celecoxib (APC) study have reported that Celebrex® (celecoxib) increased serious cardiovascular events. Similar conclusions were reached by the Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial. Both studies were reported in the March 17, 2005 issue of the New England Journal of Medicine.
Mar 26, 2005, 14:48
Research Shows that FDA’s New Recommendations will Benefit COX-2 Inhibitors Though Physicians and Patients Remain Hesitant
New FDA Advisory Committee Recommendations around COX-2s are likely to lead to prescribing gains for Bextra and Celebrex, though both physicians and patients will continue to shy away from Vioxx, even if it returns to market.New NOP World Health research shows that physicians, particularly general and family practitioners, anticipate increasing their Bextra prescribing, while internists, rheumatologists and orthopedic surgeons expect to boost their Celebrex prescribing.Patients taking Celebrex or Bextra are loyal to those products and plan to continue taking them.
Mar 24, 2005, 09:48
Celecoxib Reduces Proliferation of Cancer Cells by also Targeting Cyclin D1
Celecoxib, a selective COX-2 inhibitor with promising anti-cancer properties, has now been found to attack prostate cancer cells in a second way that differs from Vioxx (rofecoxib), another anti-inflammatory drug that also inhibits COX-2.
In studies published in the March 1 issue of the journal Clinical Cancer Research, scientists at the Weill Medical College of Cornell University revealed that celecoxib, marketed under the name Celebrex, not only targets COX-2, but also reduces levels of a key protein, cyclin D1, that’s critical for cell replication.
Mar 19, 2005, 10:19
Prospective trial confirms Rofecoxib's cardiovascular risks
The trial, known as APPROVe (Adenomatous Polyp Prevention on Vioxx), was the longest test yet of Vioxx as a chemoprevention agent, and was designed to determine whether the drug could prevent the re-growth of precancerous colon polyps in people who had already had polyps removed. The prospective chemoprevention study randomized 2,586 participants from 108 centers in 29 countries to receive either 25 mgs. of Vioxx daily or a placebo drug for three years, 2001-2004. The trial was stopped September 30, 2004 - approximately two months before its planned completion.
Feb 16, 2005, 15:22