RxPG News Feed for RxPG News

Medical Research Health Special Topics World
  Home
 
   Health
 Aging
 Asian Health
 Events
 Fitness
 Food & Nutrition
 Happiness
 Men's Health
 Mental Health
 Occupational Health
 Parenting
 Public Health
 Sleep Hygiene
 Women's Health
 
   Healthcare
 Africa
 Australia
 Canada Healthcare
 China Healthcare
 India Healthcare
 New Zealand
 South Africa
 UK
 USA
 World Healthcare
 
   Latest Research
 Aging
 Alternative Medicine
 Anaethesia
 Biochemistry
 Biotechnology
 Cancer
  Bladder
  Blood
   Multiple Myeloma
   Non-Hodgkin's Lymphoma
  Bone Cancer
  Brain
  Breast Cancer
  Carcinogens
  Cervical Cancer
  Colon
  Endometrial
  Esophageal
  Gastric Cancer
  Liver Cancer
  Lung
  Nerve Tissue
  Ovarian Cancer
  Pancreatic Cancer
  Prostate Cancer
  Rectal Cancer
  Renal Cell Carcinoma
  Risk Factors
  Skin
  Testicular Cancer
  Therapy
  Thyroid
 Cardiology
 Clinical Trials
 Cytology
 Dental
 Dermatology
 Embryology
 Endocrinology
 ENT
 Environment
 Epidemiology
 Gastroenterology
 Genetics
 Gynaecology
 Haematology
 Immunology
 Infectious Diseases
 Medicine
 Metabolism
 Microbiology
 Musculoskeletal
 Nephrology
 Neurosciences
 Obstetrics
 Ophthalmology
 Orthopedics
 Paediatrics
 Pathology
 Pharmacology
 Physiology
 Physiotherapy
 Psychiatry
 Radiology
 Rheumatology
 Sports Medicine
 Surgery
 Toxicology
 Urology
 
   Medical News
 Awards & Prizes
 Epidemics
 Launch
 Opinion
 Professionals
 
   Special Topics
 Ethics
 Euthanasia
 Evolution
 Feature
 Odd Medical News
 Climate

Last Updated: Oct 11, 2012 - 10:22:56 PM
Blood Channel

subscribe to Blood newsletter
Latest Research : Cancer : Blood

   EMAIL   |   PRINT
Treatment advances for follicular lymphoma have reduced deaths by 70%

Oct 21, 2005 - 11:22:00 PM
In the head-to-head comparison, they found that a combination of the standard therapy (a four-drug combination called CHOP, which stands for cyclophosphamide, doxorubicin, vincristine and prednisone) plus new monoclonal antibodies (rituximab or iodine-131 tositumomab) offers the best survival rate during the first four years. The team studied 179 patients who were treated with this regimen during the late 1990s, and the survival rate was 91 percent.

 
[RxPG] New treatment advances for patients with follicular lymphoma, previously considered an incurable cancer, have reduced deaths in the first four years by 70 percent. A newly published study recommends that doctors carefully choose their patients' initial therapies because there are significant differences in overall survival rates, according to researchers at the University of Rochester Medical Center's James P. Wilmot Cancer Center.

Scientists compared outcomes for 960 patients treated with three different regimens; survival rates vary from 91 percent for the newest treatments, which include monoclonal antibodies, to 69 percent for standard therapy.

"This is real evidence that the clinical advances we've made over the last 30 years are prolonging lives," said Richard I. Fisher, M.D., director of the Wilmot Cancer Center and lead author on a paper published online by the Journal of Clinical Oncology. "Some of the new therapies that include monoclonal antibodies have revolutionized treatment of this disease."

Follicular lymphoma, a slow-growing cancer of the lymphatic system, affects about 30,000 older adults each year in the U.S. Median survival has been seven to 10 years, but until this study, there was no evidence of any recent improvements.

Fisher and colleagues from the Southwest Oncology Group, Fred Hutchinson Cancer Research Center in Seattle and University of Arizona Cancer Center assessed three common therapies that have been used over the last two decades.

In the head-to-head comparison, they found that a combination of the standard therapy (a four-drug combination called CHOP, which stands for cyclophosphamide, doxorubicin, vincristine and prednisone) plus new monoclonal antibodies (rituximab or iodine-131 tositumomab) offers the best survival rate during the first four years. The team studied 179 patients who were treated with this regimen during the late 1990s, and the survival rate was 91 percent.

In the second arm of the study, the 425 patients treated during the 1980s with ProMACE-MOPP, an eight-drug, combo-chemotherapy regimen, had a 79-percent survival rate at the four-year point.

The third group of 356 patients received CHOP plus immunostimulant therapies during the 1970s; their four-year survival rate was 69 percent.

"This data gives doctors and patients real evidence that initial treatment decisions have significant impact on the length of survival," Fisher said.

Fisher has studied CHOP therapy and other combinations with the Southwest Oncology Group, one of the largest research cooperative groups, for the last three decades. He has led studies that demonstrated its effectiveness as a treatment for aggressive lymphomas.



Publication: Journal of Clinical Oncology
On the web: www.urmc.rochester.edu 

Advertise in this space for $10 per month. Contact us today.


Related Blood News


Subscribe to Blood Newsletter

Enter your email address:


 Additional information about the news article
The Wilmot Cancer Center has established one of the Northeast's largest hematologic malignancies teams, specializing in the multidisciplinary treatment of lymphomas and leukemias. Wilmot hematologists are currently comparing the two most effective therapies: CHOP plus rituximab and CHOP plus iodine-131 tositumomab.
 Feedback
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

Top of Page

 
Contact us

RxPG Online

Nerve

 

    Full Text RSS

© All rights reserved by RxPG Medical Solutions Private Limited (India)