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Last Updated: Oct 11, 2012 - 10:22:56 PM
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Latest Research : Cancer : Colon

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Variant Polymorphism May Affect Aspirin Chemoprevention of Colorectal Cancer

Mar 18, 2005 - 11:18:00 PM
Regular aspirin use has been associated with an overall reduced risk of colorectal adenoma.

[RxPG] A new study has found that, among women with a common variant polymorphism that affects an enzyme that metabolizes aspirin, regular aspirin use is associated with a decreased risk of colorectal adenoma. But regular aspirin use is not associated with the same reduction in risk of colorectal adenoma among women who have a normal form of the enzyme.

Regular aspirin use has been associated with an overall reduced risk of colorectal adenoma. More rapid aspirin metabolism may decrease the therapeutic effect of aspirin. Consequently, polymorphisms in the enzyme UGT1A6, which metabolizes aspirin, may modulate the protective benefit of aspirin.

To determine whether polymorphisms in UGT1A6 are associated with colorectal adenoma risk, Andrew T. Chan, M.D., M.P.H., of Massachusetts General Hospital in Boston, and colleagues conducted a nested case–control study of 1,062 women participating in the Nurses' Health Study. They found that among the women with variant polymorphisms, regular aspirin use was associated with a decreased risk of adenoma, and the risk decreased further with higher doses of aspirin. However, among the women the normal form of the enzyme, regular aspirin use was not associated with a reduced risk, and these women did not benefit from higher aspirin doses.

Publication: 16 March 2005 Issue of Journal of the National Cancer Institute
On the web: http://jncicancerspectrum.oupjournals.org/ 

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 Additional information about the news article
The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oupjournals.org/.
For any corrections of factual information, to contact the editors or to send any medical news or health news press releases, use feedback form

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