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Last Updated: Apr 12, 2013 - 2:00:28 AM |
Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
PAI-1 is the link between diabetes and cardiovascular disease
Researchers at the University of Vermont Cardiovascular Research Institute, Colchester, Vermont have found that increased expression in the heart of plasminogen activator inhibitor type-1 (PAI-1) is profibrotic. The results, which appear in the March 2009 issue of Experimental Biology and Medicine, implicate PAI-1 overexpression, known to accompany insulin resistance and type 2 diabetes, as a factor contributing to the high incidence of heart failure after myocardial infarction in people with diabetes.
Feb 25, 2009 - 12:30:27 AM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Insulin inhibits resistin expression and secretion
Does resistin play a role in insulin resistance? Is insulin the major regulator of resistin? A research article to be published on January 7, 2008 in the World Journal of Gastroenterology (volume 14, issue 1) addresses these questions.
Jan 16, 2008 - 2:07:29 PM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Insulin resistance in early teens may predict diabetes
The body's decreased response to insulin beginning as early as age 13 may mean increased cardiovascular disease risk by age 19, according to research reported in Hypertension: Journal of the American Heart Association.
Aug 22, 2006 - 8:26:00 PM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Race may be risk factor for insulin resistance
Black women even if their weight is normal may be at increased risk for insulin resistance, a condition associated with diabetes, high blood pressure, and heart vessel disease, according to new research by Wake Forest University School of Medicine.
Jun 27, 2006 - 2:57:00 AM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Elevation of fat-derived molecule RBP4 foretells early insulin resistance
A study in the June 15 issue of The New England Journal of Medicine (NEJM) reveals that elevated levels of a molecule called RBP4 (retinol binding protein 4) can foretell early stages in the development of insulin resistance, a major cause of type 2 diabetes as well as cardiovascular disease.
Jun 15, 2006 - 4:39:00 PM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Insulin Resistance Linked to Pancreatic Cancer
Higher insulin concentrations and insulin resistance are associated with an increased risk of pancreatic cancer in men, according to a study in the December 14 issue of JAMA. Based on the findings from several retrospective and prospective observational studies, type 2 diabetes mellitus and glucose intolerance are fairly consistent, albeit somewhat controversial, risk factors for pancreatic cancer, according to background information in the article. This is because it has been unresolved whether diabetes mellitus is involved in pancreatic carcinogenesis or the result of subclinical malignancy. One biologically plausible mechanism whereby type 2 diabetes mellitus may be related to pancreatic carcinogenesis is through the growth-regulatory effects of insulin. Experimental studies show that insulin has growth promoting effects on pancreatic cancer cells and patients with type 2 diabetes mellitus are known to exhibit hyperinsulinemia, during the early stages of their disease.
Dec 14, 2005 - 5:03:00 PM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of langerhans
Insulin resistance is a fundamental factor in non-insulin-dependent diabetes. Prolonged activation of the insulin receptor, inflammation, and excessive insulin levels can induce insulin resistance by decreasing levels of insulin receptor substrate (IRS) proteins.
Sep 5, 2005 - 1:43:00 PM
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Latest Research
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Endocrinology
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Diabetes
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Insulin Resistance
Insulin Resistance May Be the Result of Mitochondrial Dysfunction
The role of insulin resistance (IR) in type 2 diabetes, the most frequently encountered metabolic disorder in the world, has attracted much attention in recent years. Virtually all patients with type 2 diabetes have IR, which usually appears some 1020 years before the disease itself. Although the existence of the relationship between IR and type 2 diabetes is well recognized, the underlying mechanisms are poorly understood. A study by Kitt Falk Petersen and colleagues provides important new information on the underlying pathogenic mechanisms that lead to the development of IR.
Aug 16, 2005 - 8:42:00 PM
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