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Last Updated: Oct 11, 2012 - 10:22:56 PM
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Injectable Testosterone Undecanoate In Tea-seed Oil Found an an Effective Male Contraceptive

May 11, 2009 - 1:37:51 PM
No serious adverse events were reported and reproductive function returned to the normal fertile reference range in all but two participants, said a NRIFP release.

 
[RxPG] Injectable testosterone could be the way to male contraception, that is effective, reversible, and minus serious short-term side-effects, according to a new study.


'For couples who can not, or prefer not to, use only female-oriented contraception, options have been limited to vasectomy, condom and withdrawal,' said Yi-Qun Gu, National Research Institute for Family Planning - in Beijing.

'Our study shows a male hormonal contraceptive regimen may be a potential, novel and workable alternative,' he added.

Gu said this study is the largest multi-centre, male hormonal contraceptive efficacy clinical trial of an androgen preparation in the world.

Participants included 1,045 healthy fertile Chinese men aged between 20-45 years. Each participant had fathered at least one child within the two years before the study and had a normal medical history.

Their female partners were between 18 and 38 years of age and had normal reproductive function.

Males were injected monthly with 500 mg of a formulation of testosterone undecanoate - in tea seed oil for 30 months. Results showed a cumulative contraceptive failure - rate of 1.1 per 100 men in the 24-month efficacy phase.

No serious adverse events were reported and reproductive function returned to the normal fertile reference range in all but two participants, said a NRIFP release.

'Despite the present encouraging results, the long-term safety of this hormonal male contraceptive regimen requires more extensive testing with a focus on cardiovascular, prostate and behavioural safety,' said Gu.





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