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Last Updated: Sep 8, 2007 - 1:21:03 PM |
Latest Research
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Neurosciences
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Neurodegenerative Diseases
Improving Cell survival in Huntington's Disease
For the first time that it has been demonstrated that it is possible to intervene therapeutically in the proteolytic pathways and organelles that participate in the specific degradation of misfolded and abnormal proteins. This offers hope for treatment of Huntington's disease.
Feb 28, 2007 - 1:16:23 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
3-D forms link antibiotic resistance and pantothenate kinase associated neurodegeneration
The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. The story takes a twist as key differences among the structures of its main molecular characters disappear and reappear as they are assembled in the cell.
Aug 19, 2006 - 4:47:00 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
New biomarkers could help doctors spot neurodegenerative diseases
Neurodegenerative diseases like Alzheimer's and Parkinson's in their early stages can be difficult for physicians to spot, and many diagnoses are incorrect. A finding by researchers at the University of Washington and Harborview Medical Center may soon help in the diagnosis of such diseases.
Aug 14, 2006 - 12:06:00 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
Nitration Linked to Oxidative Stress Related Damage in Neurodegenerative Disorders
Parkinson's, Alzheimer's, Lou Gehrig's disease and other brain disorders are among a growing list of maladies attributed to oxidative stress, the cell damage caused during metabolism when the oxygen in the body assumes ever more chemically reactive forms.
Jun 29, 2006 - 2:43:00 AM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
REM sleep disorders can indicate early neurodegeneration
The front page of the July 2006 issue of The Lancet Neurology, the journal with the highest international impact, contains a work that shows the relationship between disorders during REM sleep and future neurodegenerative pathologies. This study has been conducted by a Hospital Clínic group led by Dr. Àlex Iranzo. This study is a good example of the fact that a correct diagnosis of sleep disorders by a specialist group can achieve a high relevancy. This diagnosis is possible in the Hospital Clínic thanks to the Multidisciplinary Unit of Sleep Disorders, which is in operation since May 2003, and which consists in 17 specialists from five areas, namely, neurology, psychiatry, psychology, otorhinolaryngology, and pulmonology. This organisation permits a multidisciplinary approach with high resolution tests, department clinical protocols and sessions, with a clear optimisation of resources. The most frequent pathologies treated in this unit are sleep apnoea, snoring, REM sleep behaviour disorders, narcolepsy, night epilepsy or hypersomnia. Only last year, 3,809 visits, 1,819 sleep tests and 40 surgical interventions were made in the unit.
Jun 29, 2006 - 2:00:00 AM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
Neurodenegerative diseases mechanisms linked to transport proteins
Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.
Jun 9, 2006 - 2:01:00 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
New Tools Developed for Studying Neurodegenerative Brain Disorders
Penn State researchers have created an elegantly simple model of an axon--the extension of a neuron that communicates with other neurons--and have used this model to reproduce a change in the axon's shape that is characteristic of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This achievement is the first of its kind in a highly simplified biophysical model system. The model provides a novel avenue for investigating the specific mechanisms that contribute to complex brain diseases. It also provides a means of discovering new kinds of drugs for the treatment of these disorders. The research will be described in a paper to be published in the 4 April 2006 issue of the Proceedings of the National Academy of Science.
Mar 22, 2006 - 8:04:00 AM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
New Tools Developed for Studying Neurodegenerative Brain Disorders
Penn State researchers have created an elegantly simple model of an axon--the extension of a neuron that communicates with other neurons--and have used this model to reproduce a change in the axon's shape that is characteristic of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This achievement is the first of its kind in a highly simplified biophysical model system. The model provides a novel avenue for investigating the specific mechanisms that contribute to complex brain diseases. It also provides a means of discovering new kinds of drugs for the treatment of these disorders. The research will be described in a paper to be published in the 4 April 2006 issue of the Proceedings of the National Academy of Science.
Mar 22, 2006 - 8:04:00 AM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
Research Suggests Abraham Lincoln Suffered from Spinocerebellar Ataxia type 5 (SCA5)
Researchers at Johns Hopkins and the University of Minnesota have discovered a gene mutation in the descendants of Abraham Lincoln's grandparents that suggests the Civil War president himself might have also suffered from a disease that destroys nerve cells in the cerebellum-- the part of the brain that controls movement.
Feb 3, 2006 - 4:19:00 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
Discovery may improve treatment of neurodegenerative diseases
A team of scientists from the Universitat Autònoma de Barcelona, led by the researcher Salvador Ventura, has developed a method that allows those parts of the proteins that set off aggregation to be identified. Using this method one is able to identify the precise zones of each protein that force these proteins to bond, aggregate and form amyloid fibres. The scientists have tested the method with different proteins involved in conformational diseases, while identifying zones that were already known for their role in protein aggregation and the neurodegenerative diseases, such as Parkinson's, Alzheimer's, and forms of spongiform encephalopathy, such as mad cow disease (BSE) and its human form, Creuzfeldt-Jacob disease.
Dec 15, 2005 - 4:14:00 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
Possible molecular origin of nervous system degeneration diseases
New research from the University of North Carolina at Chapel Hill School of Medicine points to the possible molecular origin of at least nine human diseases of nervous system degeneration.
Sep 24, 2005 - 9:07:00 PM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
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Rett Syndrome
MeCP2 - Rett Syndrome protein binds only to specific genes
Adrian Bird of the University of Edinburgh and colleagues report today in the online issue of Molecular Cell that the "Rett Syndrome protein", MeCP2, only binds to genes with a specific sequence of nucleotide bases. This knowledge will aid in the identification of the genes that are regulated by the gene MECP2. This work was supported, in part, by the Rett Syndrome Research Foundation (RSRF).
Sep 4, 2005 - 7:27:00 AM
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Latest Research
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Neurosciences
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Neurodegenerative Diseases
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Rett Syndrome
Spontaneous neuronal activity is reduced in cortex in Rett Syndrome
Sacha Nelson of Brandeis University in Waltham, MA and Rudolf Jaenisch of the Whitehead Institute of Biomedical Research in Cambridge, MA and their colleagues report online today in the Proceedings of the National Academy of Sciences Early Edition that spontaneous neuronal activity is reduced in the cortex of a knockout mouse model for the childhood neurodevelopmental disorder, Rett Syndrome. The Rett Syndrome Research Foundation (RSRF) and the McKnight Foundation funded this project.
Aug 23, 2005 - 9:19:00 PM
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